Kai1 Is Engaged in Ndrg1-mediated Metastasis Suppression through Atf3-nfkb Complex in Human Prostate Cancer
نویسندگان
چکیده
KAI1 IS ENGAGED IN NDRG1-MEDIATED METASTASIS SUPPRESSION THROUGH ATF3-NFKB COMPLEX IN HUMAN PROSTATE CANCER Wen Liu, Megumi Iiizumi-Gairani, Hiroshi Okuda, Aya Kobayashi, Misako Watabe, Sudha K. Pai, Puspa R. Pandey, Fei Xing, Koji Fukuda, Vishnu Modur, Shigeru Hirota, Kazuyuki Suzuki, Toshimi Chiba, Masaki Endo, Tamotsu Sugai, and Kounosuke Watabe Department of Medical Microbiology, Immunology & Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, 62794-9626, USA; 2 Department of Internal Medicine, 3 Gastroenterology and Hepatology, 4 Diagnostic Pathology, Iwate Medical School, Japan *Corresponding author: Kounosuke Watabe Ph.D. Tel: (217) 545-3969, Fax: (217) 545-3227, E-mail: [email protected]
منابع مشابه
KAI1/CD82 and Inhibits the Migration of Prostate Cancer EWI2/PGRL Associates with the Metastasis Suppressor
Cancer metastasis suppressor KAI1/CD82 belongs to the tetraspanin superfamily and inversely correlates with the metastatic potential of a variety of cancers. The mechanism of KAI1/CD82-mediated metastasis suppression remains unclear. In this study, we found a Mr 68,00 cellsurface protein physically associated with KAI1/CD82 and named it KASP: a KAI1/CD82-associated surface protein. Distinctive ...
متن کاملEWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells.
Cancer metastasis suppressor KAI1/CD82 belongs to the tetraspanin superfamily and inversely correlates with the metastatic potential of a variety of cancers. The mechanism of KAI1/CD82-mediated metastasis suppression remains unclear. In this study, we found a M(r) 68,00 cell-surface protein physically associated with KAI1/CD82 and named it KASP: a KAI1/CD82-associated surface protein. Distincti...
متن کاملMechanism of tumor metastasis suppression by the KAI 1 gene
presentation 1. Watabe, K. (2006) The role of KAI1 and Drg1 in metastases suppression. BenMay symposium. Chicago 2. Watabe, K. (2006) Metastasis suppressor genes, Kai11 and Drg1. Tokyo University, Japan. Invited lecture 3. Watabe, K. (2006) The role of metastases suppressor genes in prostate cancer. Kyoto University, Japan. Invited lecture 4. Watabe K (2007) Functions of metastasis suppressor g...
متن کاملRequirement of the p130CAS-Crk coupling for metastasis suppressor KAI1/CD82-mediated inhibition of cell migration.
KAI1/CD82 protein is a member of the tetraspanin superfamily and has been rediscovered as a cancer metastasis suppressor. The mechanism of KAI1/CD82-mediated suppression of cancer metastasis remains to be established. In this study, we found that migration of the metastatic prostate cancer cell line Du145 was substantially inhibited when KAI1/CD82 was expressed. The expression of focal adhesion...
متن کاملOverexpression of KAI1 suppresses in vitro invasiveness and in vivo metastasis in breast cancer cells.
KAI1 is a metastasis suppressor gene for human prostate cancer and is also involved in the progression of a variety of other human cancers. Previously, we have demonstrated that KAI1 expression was down-regulated in metastatic breast cancer cell lines as well as in highly aggressive breast cancer specimens. To determine whether KAI1 expression is responsible for the metastasis suppression in br...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2011